{"id":458,"date":"2026-06-03T21:15:38","date_gmt":"2026-06-03T21:15:38","guid":{"rendered":"https:\/\/corporate-movers-usa.com\/?p=458"},"modified":"2026-06-03T21:15:38","modified_gmt":"2026-06-03T21:15:38","slug":"a-philly-man-didnt-know-if-hed-ever-get-off-the-kidney-transplant-waiting-list-car-t-made-it-happen","status":"publish","type":"post","link":"https:\/\/corporate-movers-usa.com\/?p=458","title":{"rendered":"A Philly man didn\u2019t know if he\u2019d ever get off the kidney transplant waiting list. CAR-T made it happen."},"content":{"rendered":"<div>\n<div>\n<div><audio><\/audio><\/div>\n<\/div>\n<p>After his second kidney transplant failed, Andrew Boyd had exhausted his options. <\/p>\n<p>Read more <a href=\"https:\/\/corporate-movers-usa.com\/?p=456\">Ivory Coast will scrimmage Union II in a pre-World Cup friendly at Subaru Park<\/a><\/p>\n<div><\/div>\n<p>The Philadelphia resident\u2019s highly sensitive immune system almost certainly wouldreject another donor organ, doctors warned. For seven years, he required dialysis three times a week to replicate the kidney\u2019s blood cleansing functions. <\/p>\n<div><\/div>\n<div>\n<div>\n<div><\/div>\n<\/div>\n<\/div>\n<div><\/div>\n<p>Then doctors offered him an experimental treatment using CAR-Ttechnology invented at the University of Pennsylvania. Developed to fight cancer, the therapy works by supercharging the body\u2019s own immune system. <\/p>\n<div><\/div>\n<p>CAR-T has revolutionized the treatment of blood cancers, with success rates so high that some have called it a rare \u201ccure.\u201d <\/p>\n<div><\/div>\n<p>But since its first use in a 2010 clinical trial involving leukemia patients at Penn, efforts to broaden CAR-T\u2019s applications have advanced slowly. The therapy has not proven effective against solid cancers, although some studies have shown potential. <\/p>\n<div><\/div>\n<p>The idea of using it for transplants did not initially occur to Carl June, a Penn scientist who pioneered its development and has since explored applications for conditions from heart failure to autoimmune diseases. <\/p>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<p>In a hallway conversation five years ago, June recalls speaking with Ali Naji, a Penn transplant surgeon interested inusing CAR-T to stop patients\u2019 bodies from rejecting transplants.<\/p>\n<div><\/div>\n<p>Roughly 30% of patients on the kidney transplant waiting list are considered \u201csensitized,\u201d meaning their immune systems are likely to attack a donor organ. Naji thoughtCAR-T could be used to desensitize these patients \u2014 widening their eligibility for transplants.<\/p>\n<div><\/div>\n<p>Early results published in the <i>New England Journal of Medicine <\/i>on Wednesday showed this approach helped Boyd and another patient at Penn tosuccessfully receive kidney transplants.<\/p>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<p>For patients who are highly sensitized, \u201cI think this will be a very exciting option,\u201d said Leonardo Riella, the medical director of kidney transplantation at Massachusetts General Hospital in Boston. He was not involved in the study.<\/p>\n<div><\/div>\n<p>The trial is small and ongoing, with plans to treat at least 10 patients in total. The patients will need continued monitoring to ensure safety and determine if the effects endure. The first patient received his transplant a little over a year ago, while Boyd did roughly 10 months ago.<\/p>\n<div><\/div>\n<p>If the therapy is approved for wide use, it is likely to be expensive. The average cost of a CAR-T therapy in cancer canexceed $400,000, according to a 2024 study looking at 271 patients with commercial insurance.<\/p>\n<div><\/div>\n<p>But dialysis is also costly. Kidney disease spending totals more than $130 billion annually under the government\u2019s insurance coverage for people over 65, or roughly a quarter of Medicare spending. <\/p>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<p>Researchers hope that CAR-T will be a one-and-done treatment, followed by a transplant.<\/p>\n<div><\/div>\n<p>The lead investigator on the trial,Naji wants to see patients like Boyd able to live their full lives again. \u201cThe gratification for us is to see him not being the hostage of dialysis,\u201d he said.<\/p>\n<div><\/div>\n<p>Within a month of receiving the CAR-T treatment in early 2025, Boyd\u2019s immune system became less sensitive, making him eligible for a wider swath of transplants. <\/p>\n<div><\/div>\n<p>\u201cThat just told me that there is light at the end of the tunnel,\u201d said Boyd, a 48-year-old call center manager who lives in the Frankford neighborhood.<\/p>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<div>\n<h3>Targeting the immune system<\/h3>\n<\/div>\n<div><\/div>\n<p>Behind a highly sensitized immune system is a protein called an antibody.<\/p>\n<div><\/div>\n<p>Antibodies act like the immune system\u2019s soldiers, primed to attack foreign substances. When patients have high levels of them, their bodies are likely to reject most donor organs. B cells and plasma cells in the body function as factories to mass produce antibodies. <\/p>\n<p>Read more <a href=\"https:\/\/corporate-movers-usa.com\/?p=454\">Philly City Council is holding up a proposal to borrow $200M to buy the police headquarters building<\/a><\/p>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<p>This experimental treatment works much like traditional Chimeric Antigen Receptor (CAR) T therapy for cancer, where the body\u2019s T cells \u2014 white blood cells that play a key role in the immune response \u2014 are genetically modified to fight cancer. However, instead of targeting a tumor, this treatment trains the T cells to deplete B cells and plasma cells.<\/p>\n<div><\/div>\n<p>\u201cIt\u2019s fascinating because it\u2019s the same platform we use for cancer, and then now it\u2019s been repurposed for transplants,\u201d said June, an author on the study.<\/p>\n<div><\/div>\n<p>Of the roughly 30% of kidney transplant candidates considered \u201csensitized,\u201d a smaller subset \u2014 10 to 15% \u2014 are \u201chighly sensitized.\u201d The issue affects more women than men,usually as a result of pregnancy, Riella said. <\/p>\n<div><\/div>\n<p>Similarly, those with prior organ transplants are more likely to be sensitized after exposure to previous foreign tissues.<\/p>\n<div><\/div>\n<p>That\u2019s what happened to Boyd. After his body rejected two kidney transplants, his antibody levels produceda score of 99.99%. Essentially, he was likely compatible with only 0.01% of potential donors.<\/p>\n<div><\/div>\n<p>During his years of dialysis, he repeatedly asked his transplant coordinators if his antibody levels could be lowered,so he could be a better candidate. They always said no.<\/p>\n<div><\/div>\n<p>In previous trials,other potential treatments usually produced only temporary effects, Naji said. <\/p>\n<div><\/div>\n<p>\u201cI didn\u2019t know how long I was going to have to wait, or if I should keep waiting,\u201d Boyd said.<\/p>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<div>\n<h3>Another chance<\/h3>\n<\/div>\n<div><\/div>\n<p>Boyd was 7 years old when doctors at Children\u2019s Hospital of Philadelphia diagnosed him with a rare kidney disease, focal glomerulosclerosis, that causes kidney scarring and impairs the organ\u2019s ability to filter waste from the blood.<\/p>\n<div><\/div>\n<p>By age 14, he started dialysis for end-stage kidney disease. Months later, in 1993, he received his first transplant. That lasted until 2005, when his immune system\u2019s antibodies attacked the donor organ. <\/p>\n<div><\/div>\n<p>His body eventually rejected his next transplant too. <\/p>\n<div><\/div>\n<p>By 2018, Boyd again required dialysis.<\/p>\n<div><\/div>\n<p>Patients who are highly sensitized tend to wait years on the list. \u201cMany of these patients tend to die or get sicker even before they get an offer,\u201d Riella said. <\/p>\n<div><\/div>\n<p>Once in the experimental CAR-T trial, Boyd\u2019s immune cells were collected and engineered in the lab. In May 2025, doctors gave him a low-dose chemotherapy to knock his immune system down, then delivered the CAR-T cells by infusion.<\/p>\n<div><\/div>\n<p>Within a month, his antibody levels had declined.<\/p>\n<div><\/div>\n<p>By two months, his score was 99.567%. That meant he went from being compatible with approximately 0.01% of donors to almost 0.5%. <\/p>\n<div><\/div>\n<p>Three months later, Boyd received the call with an offer of a donor kidney.<\/p>\n<div><\/div>\n<p>On Aug. 13, 2025, he successfully received the transplant.<\/p>\n<div><\/div>\n<p>Riella called it reassuring that no serious adverse events were reported, but said a bigger trial with longer-term data will be needed to assess potential side effects.<\/p>\n<div><\/div>\n<p>He was excited at the prospect of having this option, and noted that a similarly aimedtreatment (involving an enzyme instead of CAR-T) had also recently shown promise.<\/p>\n<div><\/div>\n<div><\/div>\n<div><\/div>\n<p>Boyd remains healthy nearly 10 months later.<\/p>\n<div><\/div>\n<p>With this new kidney, he hopes to live a happy, fulfilling life, seeing friends and traveling with his wife, Leslie Boyd.<\/p>\n<p>Read more <a href=\"https:\/\/corporate-movers-usa.com\/?p=452\">Trump administration seeks new path forward with tariffs after first attempt hit legal roadblocks<\/a><\/p>\n<div><\/div>\n<p>Without the research team, \u201cwho knows where I would be right now,\u201d he said.<\/p>\n<div><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>A novel use of CAR-T helped Philadelphia resident Andrew Boyd get a kidney transplant. Early results from the clinical trial at Penn were reported in the New England Journal of Medicine on Wednesday.<\/p>\n","protected":false},"author":1,"featured_media":457,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-458","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>A Philly man didn\u2019t know if he\u2019d ever get off the kidney transplant waiting list. 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